Neoplasms of malignant nature currently occupy one of the leading places in terms of mortality among the population practically all over the world. The longer a person postpones a visit to a doctor, the more difficult and long will be the path to recovery. It is in this direction of medicine that the words that lost time is equivalent to life are as true as possible.
In the arsenal of modern pharmacology at the present time there is a mass of medicines designed to combat malignant tumors that affect the most diverse organs of the human body. For the treatment of hormone-dependent malignant tumors, medicines are widely used today - analogues of the hormones of the hypothalamus (the brain department responsible for the work of the neuroendocrine system). One of these medications is Buserelin-Long.
Composition and form of release
As the main active component of the drug is buserelina acetate. Among the auxiliary drugs, there are copolymers of lactic and glycolic acids, polysorbate-80, carmellose sodium, d-mannitol.
Today the pharmacy network of the Russian Federation offers its consumers this antitumor drug in two forms of release. One is a nasal spray (for the introduction through the nose), the second is a powdery formulation for the preparation of the solution, which is then injected intramuscularly. Actually, the second form (solution) is called "Buserelin-Long." Instruction for use contains detailed information on the principle of pharmacological effects on the human body.
Typically, a vial with a drug, an ampoule with a solvent, a disposable syringe (5 ml volume), 2 sterile needles (for solvent and for injection), a scarifier or a knife for opening the ampoule and 2 alcoholic bottles napkins.
At the initial stage of the use of this drug, there is a process of increased release of gonadotropins (hormones, the main function of which is the regulation of the functions of the sexual glands). During this period, an increase in the number of sex hormones can be observed in the blood in patients for a short time.
After 12-14 days, the action of the drug causes blockage of the gonadotropic function of the pituitary gland, which is characterized by the cessation of the secretion of hormones that stimulate the maturation of follicles and the production of lutein. The result is the inhibition of the synthesis of sex hormones in the ovaries, and as a result, the plasma levels of estradiol (the main female hormone) drop to the values characteristic for the post-menopausal period. A condition called "medical pseudomenopause" is being developed.
If this drug has been used for a long time to treat prostate cancer, the result may be a significant decrease in plasma testosterone concentration (the main male hormone). In a medical environment, this condition is called "pharmacological castration."
Taking medications based on Buselrelin in the period preceding surgical intervention for endometriosis will help reduce the size of the foci of pathology, reduce their blood supply, and attenuate inflammatory processes. In the postoperative period, the effect of the drug will reduce the process of formation of adhesions and reduce the frequency of relapses.
Patients should be aware that the effect of the drug is reversible. After the abolition of the drug, the level of sexual male and female hormones in the blood will gradually come back to normal.
Who is shown the application?
"Buserelin-Long" instruction for medication recommends taking hormone-dependent pathological processes of the human reproductive system caused by absolute or relative hyperestrogenism. Sufficient reasons for using this medication can be considered in women such diseases as uterine myoma, endometriosis, hyperplastic changes in the endometrium.
In addition, the medication is prescribed for malignant neoplasms of the prostate (hormone-dependent form, stages 3 and 4), with breast cancer (if the menstrual cycle is preserved, and the receptors for progesterone and estradiol are available).
This medication is also widely used in the procedures of in vitro fertilization (IVF). The main function of the drug in this case is to suppress the effects of the woman's own hormonal system. Thus, an artificial controlled hormonal system is formed that allows implanting a woman already fertilized with an egg. In the treatment of infertility buserelinsoderzhaschie drugs stimulate the process of ovulation.
Contraindications for taking "Buserelin-Long"
It goes without saying that you can not take Buserelin-Long for patients who are hypersensitive to the main or auxiliary components of the drug. It is also unacceptable to take this drug to pregnant women and nursing mothers.
Cautious and attentive to your health should be people who have an anamnesis records about obstruction of the urinary tract. Patients who have metastasized the malignant tumor of the prostate in the spine should also behave. At the initial stage of treatment in such patients, the probability of developing an exacerbation of the underlying disease increases.
Patients with diagnoses of hypertension, depression, diabetes should also be under the close scrutiny of the attending doctor, at least at the initial stage of taking medication.
Possible side effects
On "Buserelin", as for any complex drugs that are dispensed by prescription, negative reactions from different systems and human organs are possible.
The central nervous system can respond to medication with abnormalities in sleep and wakefulness, headaches and dizziness, decreased ability to remember information and concentration, fatigue and neuro-psychic instability. Perhaps the development of depression or deterioration of health in its presence.
Probable deviations from the senses can be deterioration of hearing and vision (sensation of blurring), noise in the ears. Sometimes patients talk about a feeling of increasing pressure on the eyes.
There may be deviations in the endocrine nature. Most often you can hear about the "tides" of blood to the face and upper chest, increased sweating, decreased sexual desire, the sensations of vaginal dryness in women, pain in the lower abdomen, mineral depletion of bones. Not often, but you can read about the drug "Buserelin-Long" reviews of patients (women), saying that during the first weeks of drug use, bleeding similar to menstrual flow was observed.
Probable deviations from the cardiovascular system include tachycardia and an increase in blood pressure in patients diagnosed with hypertension. The response of the gastrointestinal tract to the drug can be nausea, vomiting, diarrhea, constipation, marked fluctuations in one or another side of the body weight, anorexia.
Possible allergic reactions to new drugs that have buserelin as their main component (hives, itching, hyperemia of the skin). Not often, but we can talk about the development of bronchospasm, shocks (anaphylactic, anaphylactoid), edema of angioedema.
There is a possibility of changing some physiological indicators evaluated in the laboratory: hyperglycemia, decreased susceptibility to glucose, thrombocytopenia, leukopenia, increased activity of serum transaminases, abnormalities in the lipid spectrum.
Sometimes you can hear from patients about the appearance of swollen zones in the area of the ankles and feet, nosebleeds, the activation of hair growth on the body and head.
In male patients with therapy for oncology of the prostate, honey. preparations based on buserelin for 2-3 weeks after the first injection can trigger a relapse of the underlying disease, its progression. There is a risk of gynecomastia, increased sweating, decreased potency, delayed urination. If in the initial period of treatment there are pains in the bones, the instruction recommends conducting symptomatic therapy.
Application: Dosage regimen and treatment regimen
Medical preparations such as "Buserelina" should be prescribed for admission only by the attending physician. In the treatment of hormone-dependent oncological diseases of the dairy or prostate gland, the medication is prescribed for intramuscular use at a dosage of 3.75 mg (1 prick). Injections are given with a periodicity of 4 weeks. The course of therapy takes a long period of time and must be controlled by the attending doctor.
If therapy is performed for endometriosis, hyperplastic changes in the endometrium, the therapy course is the same as for oncological problems (1 injection at 4 weeks intervals). Start the treatment using the drug "Buserelin-Long" instruction regulates within 5 days of the beginning of the menstrual cycle. The course of therapy, as a rule, lasts from 4 months to six months.
Treatment regimen and dosing regimen for uterine myoma - 1 injection at 4-week intervals. The beginning of the therapeutic course should be timed to the first 5 days of the course of the menstrual cycle. The duration of therapy before surgery is at least 3 months. Conservative treatment usually lasts about six months.
The scheme of using the medication in the treatment of infertility with the use of the IVF technique looks somewhat different. The first injection of Buserelin-Long is performed either on the second day of the menstrual cycle (the onset of the follicular phase), or between the 21st day and the 24th day (the middle of the luteal phase). After 12-15 days after the injection, the amount of estrogens contained in the blood serum will drop to half of the original (blocking the pituitary function). Further, if the patient does not have cysts on the ovaries (ultrasound), and the thickness of the endometrial layer does not exceed 5 mm, one can proceed to stimulate superovulation with the help of gonadotropic hormones. These activities are carried out under ultrasound monitoring with mandatory control of the level of estradiol. The dose of "Buserelin-Longa" can be corrected in one direction or another.
Before starting the course of therapy with the use of the drug "Buserelin-Long" it will not be superfluous to get acquainted with some special recommendations contained in the instructions for the use of the drug.
Patients, women suffering from any form of depression, in the process of treatment with the drug should be under the close attention of the attending physician. Also strict medical control requires the procedure for induction of ovulation. Women should be aware that during the initial period of the drug use there is a possibility of development of the ovarian cyst.
Patients before the start of therapy with the use of "Buserelina" should refuse to take hormonal contraceptive drugs, but for 2 months from the beginning of the course to use non-hormonal methods to prevent the onset of pregnancy.
- Important! Women, before proceeding with medication, it is recommended to exclude the fact of pregnancy.
At the end of the course of therapy, the functioning of the ovaries will be restored. The first menstruation usually comes 3 months after the end of treatment.
As for male patients, in order to avoid the development of negative manifestations at the beginning of therapy with Buserelin, it is recommended to start taking antiandrogen at least 2 weeks before the first injection and take them during the crescent after the injection.
In addition, if you study the antitumor drug Bucereling-Long reviews of health workers or even read the instructions carefully, you will find out that those patients who, by their work activity, drive vehicles or are involved in works that require high concentration of attention and the speed of psychomotor reactions, you should be especially careful when taking the medication.
Interaction with other substances and medications
Within the framework of our article, it remains to consider a few more points concerning the drug "Buserelin-Long." The price of the drug, its interaction with other medicines, analogues and patient reviews - any of these issues are of interest to people intending to purchase the drug. Below we dwell in more detail on each of them.
Like any modern medicine developed using high technologies, Buserelin-Long obeys certain principles, interacting with other medicinal substances. For example, the simultaneous use in the treatment of the drug we are considering and drugs that contain sex hormones during the induction of ovulation can lead to the development of a condition called the ovarian hyperstimulation syndrome.
A parallel reception of Buserelin-Long and drugs of hypoglycemic effect reduces the effectiveness of the latter.
The price range. Analogues
How much does Buserelin-Long cost? The price of the drug can make you think. In the pharmacy chain of Moscow, consumers can purchase this drug for an amount ranging from 3,500 to 5,500 rubles. It is necessary to think, that in the remote regions of Russia the medicinal product costs even more expensively. However, the effectiveness of the drug fully justifies its fairly high cost.
Spray "Buserelin" is cheaper than the drug in bottles ("Buserelin-Depot" - from 3900 to 7000 rubles), and it costs about 800-900 rubles.
As for analogous antitumour agents, for the medicine "Buserelin-Long" analogues (structural) for the active substance are medicines "Buserelin-FSintez" (spray), "Buserelin-Depot" (lyophilizate for suspension, intramuscular injection), " Buserelina acetate "(0.2% vial)," Suprefakt "and" Suprefakt Depo ".
Opinion of patients about the drug "Buserelin-Long"
Like any modern drug, "Buserelin-Long" reviews patients has both a positive and a negative direction. Those who have a positive experience of treatment with medicines containing Buserelin, speak of good results. A certain percentage of women say that there are light tides, some have small discharge. After the termination of therapy within 1-2 months the menstrual cycle is restored. In male patients, after the cessation of treatment, Busereline, the sexual desire and potency are fully restored.
Another part of the patients remained dissatisfied with the treatment, because, according to their comments, the drug provoked the development of a whole list of side effects. Someone talks about a bad skin condition, severe headaches, dizziness and constant nausea. In such cases, there may be several reasons. You can not discount the presence of individual intolerance buserelin. There is only one way out - to change the drug (of course, only on the instructions of the treating doctor). Negative consequences may result from non-observance of the drug regimen developed by a specialist and changing the dosage of the drug taken.
In any case, no matter how good or bad the patients' reviews describing honey are. drugs (Buserelin-Long and others like that), the decision to prescribe the medicine must be made only by the treating doctor, who will take into account all the individual characteristics of the course of the disease in each individual patient. Only in this case it is possible to hope for achievement of positive results of therapy without risk to cause serious damage to a state of health.