Neoplasms of malignant nature currently occupy one of the leading places in terms of mortality among the population almost all over the world. The longer a person postpones a visit to the doctor, the harder and longer the path to recovery. It is in this direction of medicine that the words that lost time is equivalent to life would be the most correct.
In the arsenal of modern pharmacology, there is currently a mass of medicines designed to fight against malignant tumors that affect the most diverse organs of the human body. For the treatment of hormone-dependent malignant tumors, medicines are widely used today - analogues of the hormones of the hypothalamus (the brain department responsible for the functioning of the neuroendocrine system). One of these drugs is “Buserelin-Long”.
Composition and forms of release
The main active ingredient of the drug is buserelin acetate. Among the auxiliary substances, the copolymers of lactic and glycolic acids, polysorbate-80, carmellose sodium, and d-mannitol are included in the drug.
Today, the pharmacy network of the Russian Federation offers its consumers this anticancer drug in two forms of release. One is a nasal spray (for insertion through the nose), the second is a powder composition for preparing a solution, which is then injected intramuscularly. Actually, the second form (solution) is also called “Buserelin-Long”. Instructions for use contains detailed information on the principle of pharmacological effects on the human body.
Usually in a blister box enclosed in a cardboard box, there is a bottle of medication, a vial with a solvent, a disposable syringe (5 ml), 2 sterile needles (for solvent and for injection), scarifier or opener for opening the ampoule and 2 alcohol napkins.
At the initial stage of the use of this drug, there is a process of enhanced release of gonadotropins (hormones, the main function of which is to regulate the functions of the sex glands). During this period, an increase in the amount of sex hormones may be observed briefly in patients with blood.
After 12-14 days, the action of the drug causes a blockage of the gonadotropic function of the pituitary gland, which is characterized by the termination of the secretion of hormones that stimulate the maturation of follicles and the production of lutein. The result is inhibition of the synthesis of sex hormones in the ovaries, and, as a result, the plasma level of estradiol (the main female hormone) drops to the levels typical for the post menopausal period. A condition called by medical workers “drug pseudomenopause” is developing.
If this drug is used for a long enough period of time for the treatment of prostate cancer, the result may be a significant decrease in the blood plasma concentration of testosterone (the main male hormone). In the medical environment, this condition is called "pharmacological castration."
Taking medication on the basis of buserelin in the period preceding surgical intervention for endometriosis will help reduce the size of the lesions of the pathology, reduce their blood supply, attenuation of inflammatory processes. In the postoperative period, the influence of the drug will reduce the process of formation of adhesions and reduce the frequency of relapses.
Patients need to be aware that the effect of the drug is reversible. After discontinuation of the drug, the level of male and female sex hormones in the blood will gradually return to normal.
Who is indicated for use?
"Buserelin-Long" instruction to the drug recommends taking with hormone-dependent pathological processes of the human reproductive system, caused by absolute or relative hyperestrogenism. Sufficient grounds for the use of this drug can be considered in women diseases such as uterine fibroids, endometriosis, endometrial hyperplastic changes.
In addition, the drug is prescribed for malignant tumors of the prostate gland (hormone-dependent form, stage 3 and 4), for breast cancer (if the menstrual cycle is preserved, and progesterone and estradiol receptors are available).
It is also a drug widely used in in vitro fertilization procedures (IVF). The main function of the drug in this case is to suppress the effects of the woman’s own hormonal system. Thus, an artificial controlled hormonal system is being “formed”, which allows an already fertilized egg to be implanted in a woman. In the treatment of infertility, boserelin-containing medications stimulate the process of ovulation.
Contraindications for taking "Buserelin-Long"
It goes without saying that Buserelin-Long cannot be taken by patients who are hypersensitive to the main or auxiliary components of the drug. It is also unacceptable to take this drug to pregnant women and nursing mothers.
Careful and attentive to their well-being should be people who have a history of obstruction of the urinary tract. Patients whose malignant prostate cancer has metastasized to the spine should also behave. At the initial stage of treatment in such patients, the likelihood of an exacerbation of the underlying disease increases.
Patients with diagnoses of arterial hypertension, depression, and diabetes mellitus should also be under the scrutiny of the attending doctor, at least at the initial stage of taking the medicinal drug.
Possible adverse events
On "Buserelin", as on any complex drugs, prescription of a doctor, there may be negative reactions from different systems and organs of man.
The central nervous system can respond to medication by abnormalities in sleep and wakefulness, headaches and dizziness, decreased ability to remember information and concentration, fatigue and neuropsychiatric instability. You may develop depression or deterioration of health in its presence.
Impairment of hearing and vision (sensation of blurring), tinnitus can be probable deviations from the sense organs. Sometimes patients talk about the feeling of increasing pressure on the eyes.
Perhaps the appearance of deviations of the endocrine nature. Most often you can hear about the "tides" of blood to the face and upper chest, about increasing sweating, about reducing sexual desire, about feelings of vaginal dryness in women, pain in the lower abdomen, and mineral exhaustion of the bones. Not often, but you can read about the drug "Buserelin-Long" reviews of patients (women), stating that during the first weeks of use of the drug was observed bleeding, similar to menstrual flow.
Probable abnormalities in the cardiovascular system include tachycardia and an increase in blood pressure in patients diagnosed with hypertension. The response of the gastrointestinal tract to the drug may be nausea, vomiting, diarrhea, constipation, noticeable fluctuations in one direction or another of body weight, appetite disturbances.
Possible allergic reactions to new drugs that have in their composition buserelin as the main component (urticaria, pruritus, skin flushing). Not often, but we can talk about the development of bronchospasms, shocks (anaphylactic, anaphylactoid), edema of angioedema.
There is a possibility of a change in some physiological indices assessed under laboratory conditions: hyperglycemia, decrease in susceptibility to glucose, thrombocytopenia, leukopenia, increased activity of serum transaminases, abnormalities in the lipid spectrum.
Sometimes you can hear from patients about the appearance of edematous zones in the area of the ankles and feet, about nosebleeds, about activating the growth of hair on the body and head.
In male patients with treatment for oncology of the prostate gland honey. drugs based on buserelin for 2-3 weeks after the first injection can provoke a relapse of the underlying disease, its progression. There is a risk of gynecomastia, increased sweating, reduced potency, urinary delay. If in the initial period of treatment there is pain in the bones, the instruction recommends symptomatic therapy.
Application: dosing regimen and treatment regimen
Medications like Buserelin should be prescribed only by your doctor. When treating hormone-dependent oncologic diseases of the mammary or prostate glands, the drug is prescribed intramuscularly at a dosage of 3.75 mg (1 shot). Injections are made at intervals of 4 weeks. The course of therapy takes a long period of time and must take place under the supervision of the attending doctor.
If there is therapy for endometriosis, endometrial hyperplastic changes, the scheme of the therapeutic course is the same as for cancer problems (1 injection with a frequency of 4 weeks). Begin treatment with the use of the drug "Buserelin-Long" instruction regulates within 5 days from the start of the menstrual cycle. The course of therapy usually lasts from 4 months to six months.
Treatment regimen and dosing regimen for uterine myoma - 1 injection at intervals of 4 weeks. The beginning of the therapeutic course should be timed to the first 5 days of the flow of the menstrual cycle. The duration of therapy before surgery is at least 3 months. Conservative treatment usually lasts about six months.
The scheme of using a medical product in the treatment of infertility with the use of IVF techniques looks somewhat different. The first injection of “Buserelin-Long” is made either on the second day of the menstrual cycle (beginning of the follicular phase), or in the period from the 21st to the 24th day (middle of the luteal phase). After 12–15 days after the injection, the amount of estrogen contained in the serum will drop to half of the initial (blocking the pituitary function). Further, if the patient does not have cysts on the ovaries (ultrasound examinations), and the thickness of the endometrial layer does not exceed 5 mm, one can proceed to stimulate superovulation with the help of gonadotropic hormones. These activities are carried out under ultrasound monitoring with mandatory monitoring of estradiol levels. The dose of "Buserelin-Long" can be adjusted in one direction or another.
Before starting a course of therapy with the use of the drug "Buserelin-Long," it will not be superfluous to familiarize yourself with some of the special recommendations that are contained in the instructions for use of the drug.
Patients-women suffering from any form of depression, in the process of drug treatment should be under the scrutiny of the attending physician. Also, strict medical control requires the procedure of induction of ovulation. Women need to keep in mind that in the initial period of use of the drug is likely to develop an ovarian cyst.
Patients before starting therapy with Buserelin should refuse to take hormonal contraceptive drugs, but for 2 months from the start of the course, use non-hormonal methods of preventing pregnancy.
- Important! Women, before embarking on medication, it is recommended to exclude the fact of pregnancy.
At the end of the course of therapy, the functioning of the ovaries will be restored. The first menstruation usually comes 3 months after the completion of treatment.
As for male patients, in order to avoid the development of negative manifestations at the beginning of “Buserelin” therapy, it is recommended to start taking anti-androgens at least 2 weeks before the first injection and take them throughout the crescent after the injection.
In addition, if you study the feedback of health workers about the antitumor drug "Busereling-Long", or at least carefully read the instructions, you can find out that for those patients who, by the nature of their labor activity, drive vehicles or are related to work that requires a high concentration of attention and the speed of psychomotor reactions, should be especially careful when taking medication.
Interaction with other substances and drugs
In our article, it remains to consider a few more points regarding the drug "Buserelin-Long." The price of the drug, its interaction with other medicines, analogues and patient reviews - any of these questions are of interest to people who are going to buy the medicine mentioned. Below we will dwell in more detail on each of them.
Like any modern medicine, developed with the use of high technologies, Buserelin-Long obeys certain principles, interacting with other medicinal substances. For example, the simultaneous use in the treatment of the medicine we are considering and drugs that have sex hormones in their composition during the induction of ovulation may cause the development of a condition called the ovarian hyperstimulation syndrome.
A parallel reception of "Buserelin-Long" and hypoglycemic drugs reduces the effectiveness of the latter.
Price range. Analogs
How much is Buserelin Long? The price of the drug may make you think. In the Moscow pharmacy network, consumers can purchase this drug for an amount ranging from 3,500 to 5,500 thousand rubles. It is necessary to think that in remote regions of Russia the drug costs even more. However, the effectiveness of the drug fully justifies its relatively high cost.
Spray "Buserelin" cheaper than the drug in bottles ("Buserelin-Depot" - from 3900 to 7000 rubles), and costs about 800-900 rubles.
As for similar anticancer drugs, the drug "Buserelin-Long" analogs (structural) for the active substance are drugs "Buserelin-FSintez" (spray), "Buserelin-Depot" (lyophilisate for the manufacture of suspensions, the introduction intramuscularly), " Buserelin Acetate "(0.2% vial)," Suprefakt "and" Suprefakt-Depo ".
Opinion of patients about the drug "Buserelin-Long"
Like any modern drug, "Buserelin-Long" patient reviews have both positive and negative orientation. Those who have a positive experience of treatment with drugs containing buserelin, speak of good results. A certain percentage of women insist that there are slight hot flashes, some have a small discharge. After the end of therapy, the menstrual cycle is restored within 1-2 months. In male patients, after cessation of treatment with Buserelin, both sexual desire and potency are fully restored.
Another part of the patients was not satisfied with the treatment, because, according to their comments, the drug provoked the development of a whole list of side effects. Someone talks about poor skin condition, severe headaches, dizziness, and constant nausea. In such cases, there may be several reasons. You can not discount the presence of individual intolerance to buserelin. Here, the only way out is to change the drug (of course, only as directed by the attending physician). Negative consequences can result from non-compliance with the medication regimen developed by a specialist and changing the dosage of the drug being taken.
In any case, no matter how good or bad the patient reviews describing honey are. drugs ("Buserelin-Long" and the like), the decision on the appointment of a drug should be made only by the attending doctor, who will take into account all the individual characteristics of the course of the disease in each individual patient. Only in this case it is possible to hope to achieve positive results of therapy without the risk of causing serious damage to the state of health.