Pain, scientists believe a factor in forcing a person to pay attention to themselves and their health. Without it, people would not even know if there was something wrong in the body, its internal reserves are not enough to solve the problem on their own, and outside help is needed. Discomfort attracts the attention of a person to a particular organ in order to receive treatment before it is too late.
Pains are of varying intensity, and for their relief in each case may require different activities. In one case, pills may be sufficient, in the other, injections or droppers are required, in the third case, immediate surgical intervention with the use of narcotic drugs will be necessary.
Upsarin UPSA is one of the most widely known drugs in pills designed to relieve or even relieve pain.
Main components and release form
The main component of the drug is acetylsalicylic acid - to consumers it is better known as “Aspirin” - with a volume of 500 mg per tablet. Additionally, aspartame, povidone, crospovidone, and anhydrous forms of substances — sodium carbonate, sodium bicarbonate, citric acid, sodium citrate, act as constituents. A nice addition is the natural flavor "orange".
The main dosage form in which the drug "Upsarin UPSA" is offered to consumers is effervescent tablets. They have a round flat shape, slightly bevelled at the edges. On one of the surfaces is embossed risk. In the process of dissolution in a liquid, gas bubbles are released. Most often, pharmacies offer consumers strips with four tablets each. Packaging - cardboard packs in which there can be 16 or 100 pieces of tablets (4 or 25 strips).
The drug belongs to the group of nonsteroidal anti-inflammatory drugs. The mechanism of action on the human body consists in the indiscriminate suppression of the activity of cyclooxygenase-1 and -2 (COX-1 and COX-2), which are involved in the synthesis of prostaglandins. These elements are responsible for the formation of pain and the creation of a puffiness area in the inflammatory focus.
Tablets "Upsarin UPSA" are characterized by a whole complex of effects on the human body - the relief of pain, the removal of inflammatory processes and a moderately pronounced decrease in body temperature. When the amount of prostaglandins in the body decreases, the heat passes. This is due to increased sweating and an increase in the lumen of blood vessels.
In platelet cells, the drug inhibits the synthesis of thromboxane A2, thus reducing the likelihood of thrombus formation, aggregation (adhesion, cell adhesion) and adhesion (adhesion of surfaces of dissimilar solid and liquid bodies) of platelets.
Antiplatelet effect, achieved even after a single dose of the drug, can persist for 7 days. Studies have shown that the severity of this effect is brighter in men, in women it is more short-term.
The drug "Upsarin UPSA", the use of which is indispensable for prophylactic purposes in patients with a predisposition to myocardial infarction, significantly reduces the likelihood of developing this disease, reduces the mortality rate when establishing the diagnosis of unstable angina.
The main indication for the use of the drug "Upsarin UPSA" manual calls the pain a very different etiology. These can be headaches and toothaches, myalgia and neuralgia, arthralgia, lumbago, algomenorrhea, and radicular syndrome. Quite often, doctors use this drug to facilitate the occurrence of febrile syndrome, as a rule, accompanying diseases of infectious and inflammatory nature.
The drug is widely used in the presence of diseases of the cardiovascular system. It is prescribed for angina (unstable form), with myocardial ischemia, which proceeds painlessly, if the patient has several factors simultaneously provoking IHD, with myocardial infarction. In vascular surgery, "Upsarin UPSA" is used after surgical interventions for the purpose of prosthetic heart valves, coronary balloon angioplasty, installation of a special stent.
A well-proven drug in the treatment of aortoarteritis, with lesions of coronary vessels of non-atherosclerotic nature, with mitral valve prolapses, with acute thrombophlebitis, pulmonary infarction, Dressler syndrome.
Who is contraindicated?
In the list of contraindications for therapy with the drug "Upsarin UPSA" instructions for use contains a number of diseases and factors. People with hypersensitivity to any of the components that make up NSAIDs should not take it. Do not prescribe the drug to patients suffering from various hemorrhagic diseases (hemophilia, hypopromthrombinemia, von Willebrand disease, etc.). The drug is contraindicated in those diagnosed with the aspirin triad (the simultaneous presence of polyps in the nose and adjacent sinuses in the stage of relapse, asthma, and hypersensitivity to acetylsalicylic acid).
The basis for refusing to take the drug "Upsarin UPSA" instruction considers the presence of vitamin K deficiency, pathological changes in the liver and kidneys, pregnancy and lactation.
With great precautions and with additional consultation with narrow specialists, it is prescribed NSAIDs if there is a history of ulcerative lesions of the gastrointestinal tract, with CHF in a decompensated state, with gout, urate nephroluritiasis, hyperuricemia, portal hypertension, phenylketonuria.
Possible undesirable manifestations
As with any drug with a wide spectrum of action, the instruction “Upsarine UPSA” (effervescent tablets) gives a decent list of possible adverse events.
As allergic reactions may cause skin rashes, angioedema, bronchospasm, "aspirinova triad". The gastrointestinal tract may react to the drug with the appearance of nausea, vomiting, diarrhoea, pain in the epigastric region. Possible deterioration of appetite, increased liver transaminases. If the vomit has the appearance of coffee grounds or stool painted black like tar, you can suspect the development of bleeding in the stomach or the intestine.
In rare cases, talk about deviations in the functioning of the urinary system. Serious disruptions are fraught with a response to aspirin of the blood-healthy system: anemia, leukopenia, thrombocytopenitis, hyperbilirubinemia are possible. The increase in blood clotting time, the development of hemorrhagic syndrome - this may be the reaction to aspirin from the blood coagulation system (perhaps, although it happens rarely).
In the doses recommended by the attending physician, usually "Upsarin UPSA" does not cause undesirable effects. Patients should know that any, even the simplest drug can cause side effects. This usually happens for several reasons. Either the medicine is taken for a sufficiently long period, either in the highest possible doses, or in combination with several other medicines. It is important to remember that if there are still side effects of the drug, the patient should stop taking it and consult a doctor.
Exceeding the permissible dose: symptoms, treatment
If you take the Upsarin UPSA pills uncontrollably (the medication instruction confirms this), an overdose is possible. The consequences may be the most serious. Of the most likely manifestations, we can expect the development of bleeding, anuria, drowsiness, collapse. In some particularly severe cases, central hyperventilation may occur. At the initial stage of this condition, respiratory alkalosis develops (shortness of breath, asphyxiation, cold, sticky sweat, cyanosis of the body, hands and feet). If intoxication increases, paralysis of the respiratory center and serious deviations in the processes of oxidative phosphorylation may occur. These processes cause the development of respiratory acidosis, coma.
Currently, there is no special antidote. When establishing the fact of overdose, it is necessary to carry out gastric lavage and enterosorbents. Also conduct symptomatic therapy. For the rapid removal of the drug from the body, the appointment of hemodialysis and forced gastric diuresis will be effective. You can also increase the rate of purification of the body from aspirin by increasing the reserve alkalinity. Here it is important to remember that intensive infusion therapy in elderly patients can trigger the development of pulmonary edema. In such cases, carry out artificial ventilation of the lungs with a special composition enriched with oxygen.
Dosing regimen, rules of application
Proper use of the drug is a technique previously dissolved in water or juice of the medication. The maximum dose of "Upsarin UPSA" - 500 mg once, but not more than 6 times during the day (with strong pain and high temperature). The minimum time interval between doses should not be less than 4 hours. For elderly patients, the daily volume is reduced to 4 doses of 500 mg.
As an antipyretic medication is permissible to take within 3 days, as an anesthetic for 5.
For the treatment of diseases of the cardiovascular system, acute rheumatism, with cerebral thromboembolism, etc., the dose of the drug is chosen strictly by the individual physician based on the severity of the patient's health condition.
If the drug "Upsarin UPSA 500" is taken for a long time, regular monitoring of the main blood parameters is necessary. Also for the presence of hidden blood must be controlled fecal masses.
If a patient is undergoing a surgical procedure, aspirin-containing medications should be discontinued for at least 7 days. In pediatrics, it is forbidden to use acetylsalicylic acid for the treatment of viral pathology due to the possible risk of developing Reye's syndrome (non-stop vomiting, enlarged liver, the state of acute encephalopathy).
In individuals predisposed to gout, taking the drug may trigger a new gouty attack.
For pregnant women, the use of the drug "Upsarin UPSA" in the first trimester is prohibited due to the risk of intrauterine malformations of the child (splitting of the upper palate). Also, aspirin reduces the intensity and speed of the flow of labor, which is associated with slowing the process of prostaglandin synthesis.
Teratogenic effects of NSAIDs are characterized by hypertension in the pulmonary circulation, closure (premature) of the ductal lumen. Perhaps the development of hyperplasia of the blood vessels of the lungs.
Instructions for use does not recommend the use of the drug in parallel with diuretics, antihypertensive, urikozuricheskimi drugs. Next you need to know that aspirin enhances the effectiveness of reserpine, other NSAIDs, indirect anticoagulants, thrombolytics, sulfonamides, oral hypoglycemic drugs, analgesics of narcotic origin, drug inhibitors of platelet aggregation (adhesion, adhesion). The toxic effects of methotrexate may increase. The simultaneous use of aspirin and ethanol-containing agents, GCS and ethanol increases the likelihood of gastrointestinal bleeding.
Similar in composition include the following drugs: "Aspivatrin", "Necstream", "Flupirtin", "Taspir", "Acetylsalicylic acid".
In addition to similar in composition, there are also medicinal products similar to the drug "Upsarin UPSA" (feedback from specialists and patients is a confirmation of this) in its principle of influence on the human body. Kofitsil-Plus, Tsefekon N, Eksedrin, Zoreks Utro, Salitsilamid can be definitely referred to such medicines.
Opinion of consumers about the drug "Aspirin UPSA"
Because medicine is a modern highly effective non-steroidal anti-inflammatory agent developed using modern technology, of course, he may not have the same implications for all its users. The majority of patients took this medication to relieve febrile syndrome (fever, pain, inflammation). "Upsarin UPSA" (500 mg) manual recommends that in such cases from 3 to 5 days. The vast majority of consumers were pleased with the results. Within 3-5 days the condition improved significantly decreased to normal values temperature.
However, there is a small percentage of consumers in whom the drug provoked the development of side effects, most often manifested in nausea, vomiting, fluctuations in blood pressure, and drowsiness. Such conditions could be the result of an incorrect dosage regimen or excessive doses of the drug. Some consumers had a history of established hypersensitivity to acetylsalicylic acid, which could also cause undesirable effects.
In any case, before you start taking any medication, even if it looks harmless to the patient (what could be simpler than the well-known aspirin?), You should consult with your doctor, who will evaluate the patient's health, and, based on the results, the regimen of the drug "Upsarin UPSA" and determine the optimal dosage for each individual patient. Only in this case, it is possible to obtain a positive result with minimal risk of undesirable effects.