The medicine "Pangrol 10000" (the instruction is attached to the drug and must be carefully studied before it is used) is used to treat pancreatic pathologies and compensates for the lack of enzymes. It is manufactured by the famous pharmaceutical company Berlin-Chemie. Reviews mark its 100% effectiveness. It is said that the drug has virtually no flaws and rarely causes negative phenomena.

The composition of the drug and its release form

Pangrol 10000 drug is available in convenient enteric capsules. The composition of this drug is represented by the active ingredient Pancreatin, which in one tablet contains about 153.5 mg.

Additional elements in the composition of the capsules are:

  • croscarmellose sodium;
  • microcrystalline cellulose;
  • castor oil;
  • anhydrous colloidal silicon dioxide;
  • magnesium stearate.

Dragee body consists of gelatin, titanium dioxide, yellow and red iron dye oxide. The drug cover contains gelatin, titanium dioxide, a yellow quinoline dye, as well as indigo carmine.

The drug is available in the form of hard gelatin capsules having the shape of a cylinder with rounded ends. The tablets are painted in a light orange color, and their covers are yellowish-green. Each capsule contains twenty cylindrical mini-tablets inside. They have a light beige color and solid soluble shell.

Capsules are soluble in 10,000 IU and 25,000 IU. Drops are packed in a polypropylene bottle of 20, 50 and 100 units. Its cap twists on the neck and is equipped with a desiccant. Pharmacies "Pangrol 10000" packaged in a cardboard box is sold in pharmacies. Instructions for use attached to it.

Store the drug should be at a temperature not exceeding 25 ° C, out of the reach of children and protected from sunlight. The shelf life of the drug from the date of manufacture is two years. The pharmacy is available without a prescription.

Pharmacological properties

Medicine Pangrol 10000: instructions for use, analogues, reviews

The active ingredient of the drug "Pangrol 10000" (instructions for the drug warns about contraindications and possible side effects) is pancreatin, which is a powder made from the pancreas of pigs. Contains special enzymes that help break down fats, proteins and carbohydrates that enter the body with food.

Pancreatin has a proteolytic, lipolytic, and amylolytic properties. Replenishes the deficiency of pancreatic enzymes. A positive effect on the functioning of the gastrointestinal tract. It normalizes the processes of digestion.

The capsules in the gelatin shell quickly dissolve in the gastric organ, where they release the mini-pills they contain. The latter dissolve only in the intestine. They are the same as the capsule itself, covered with a soluble shell and resistant to acidic gastric environment. So pancreatic enzymes are protected from inactivation in the acidic environment of the gastric organ.

This form of drug release was not chosen by chance, because it promotes the even distribution of enzymes and ensures the mixing of mini-tablets with the contents of the intestine. The dissolution of their shell and the activation of enzymes are in the weakly alkaline and neutral environment of the small intestine.

The active ingredient of the drug is not absorbed in the gastrointestinal tract and goes only with feces.

Indications for use of the drug

It is strongly advised to take the Pangrol 10000 medication instruction only after a doctor is prescribed. The indications for the use of capsules are substitution treatment for inadequate work of the pancreas in children and adults. This is usually chronic pancreatitis and cystic fibrosis. Use the drug for pancreatic cancer, as well as patients who have undergone surgery on the pancreas or stomach.

The drug is prescribed to patients who have undergone irradiation of the organs of the gastrointestinal tract, where there is a violation of the process of digestion of food, diarrhea and flatulence. The drug, in this case, involve in complex treatment. Assign "Pangrol 10000" in the narrowing of the pancreatic duct, which occurs due to the formation of a tumor or because of the presence of gallstones.

The indications for use are Shvachman-Diamond syndrome and subacute pancreatitis, as well as other pathologies with exocrine pancreatic insufficiency.

As a rule, pancreatic enzyme deficiency occurs when:

  • gastrointestinal upset;
  • intestinal infections;
  • the occurrence of irritable bowel syndrome;
  • by consuming food that is long and difficult to digest.

Also, the drug is drunk in preparation for the ultrasound and X-ray examination of the organs in the abdominal cavity.


You should consider all contraindications before using the drug "Pangrol 10000". Instructions for use for children warns that the dosage when using this tool should not exceed that prescribed by a doctor, otherwise there may be adverse effects in the body.

Also, before using the capsules should take into account contraindications that indicate that the drug can not be used for pancreatitis and chronic pancreatitis, which are in the acute stage. The prohibition of capsule use is excessive sensitivity to the active substance “Pangrol 10000” and its auxiliary components.

There is no clinical data on the use of the drug during pregnancy. When testing animals, the absorption of enzymes extracted from the pancreas of pigs was not observed, therefore, no toxic effect on the fetus and the reproductive system of the woman is assumed.

It is possible to use “Pangrol 10000” for pregnant women when the expected benefit for the expectant mother significantly exceeds the likely risk to the fetus.

In studies of the drug in animals, there were no negative reactions from the effects of porcine enzymes, so no negative effect on the baby who takes breast milk is expected. Therefore, women are allowed to use this medicine during lactation.

Capsules "Pangrol 10000": instructions for use for children and adults

The drug is taken orally with water. The dosage of the drug is selected individually by a doctor. Depends on the degree of development of the disease, the amount of food and consumed products.

If there are no special medical prescriptions, then the adult population should use 2-4 tablets with each meal. Capsules are swallowed whole, not liquid, squeezed water.

If a person cannot swallow a whole capsule (usually children or elderly people), then it can be opened and the entire contents poured into empty containers, and only then can take the drug in the form of mini-tablets, drinking plenty of water. It is allowed to mix the medicine with liquid food (porridge, mashed potatoes, soup), but this combination should be consumed immediately and cannot be stored.

It is recommended to increase the dosage only with the permission of the doctor and under his careful control. To focus in this case should be on the existing symptoms of the disease. The daily rate of enzymes should not exceed 15,000-20000 lipase units per kilogram of weight.

How long can you take "Pangrol 10000"? The therapeutic course of this drug is determined by the doctor and depends on the severity of the disease.

Prescribing the drug Pangrol 10000 to babies recommends instructions for children at a dose of 500-1000 lipase units for one kilogram of the child's weight. So, set the dose at each meal. Suitable drug "Pangrol 10000" for infants. The dose here is set by the pediatrician individually, depending on the health of the baby.

Using the drug for cystic fibrosis should take into account body weight. For babies under four years of age, the calculation is made for each meal, one thousand lipase units per one kilogram of the child’s weight are taken. “Pangrol 10000” for children over four years of age is prescribed at the rate of five hundred lipase units per kilogram of body weight. The resulting amount of the drug is consumed during basic meals (in the morning, at lunch and in the evening).

The dosage for each patient is selected individually based on the stage of the disease, steatorrhea is controlled, and patients must also follow the necessary diet.

For most individuals, the daily rate is 10,000 lipase units / kg of body weight or 4,000 lipase units / g of eaten fat.

Side effects and overdose

The pangrol 10000 medicine, if used improperly, can cause a number of side effects, including nausea, vomiting and flatulence. As a rule, gastrointestinal disorders are not negative reactions to the medication, but act as the main symptoms that indicate the underlying disease.

Even when taking capsules, patients had abdominal pain, diarrhea, rashes on the skin, urticaria, and itching.

Overdose is often associated with the use of too large doses of pancreatic organ enzymes. In patients with cystic fibrosis manifested in the form of hyperuricuricuria and hyperuricemia. If the above symptoms occur, the drug should be immediately stopped and symptomatic treatment should be carried out.

Research on the interaction of "Pangrol 10,000" with other drugs was not conducted.

Special instructions for use

Pangrol 10000 tablets can cause fibrosing colonopathy in patients receiving increased doses. For the prevention of such phenomena, as well as at the first signs of the appearance of negative symptoms and the variability of the nature of the disease, you must undergo a medical examination of the intestine to prevent damage to this organ. This is especially true of patients receiving the drug in a dose of more than 10,000 lipase units per kilogram of body weight per day.

The drug "Pangrol 10000" does not affect the ability to drive a vehicle and other mechanisms. It also does not interfere with engaging in potentially dangerous activities that require quick response and increased attention.

The medicine "Pangrol 10000" has a lot of structural analogues, similar to the indicated preparation by the active ingredient. The most popular substitutes are:

  • Creon.
  • "Gastenorm Forte".
  • "Mezim."
  • Mikrasim.
  • Pancreatin.
  • Panzikam.
  • Enzistal.
  • Panzim Forte.
  • "Festal N".

It is not necessary to select analogs of “Pangrol 10000” independently; it is better to seek help from a specialist who is fully able to assess the patient’s condition and prescribe a suitable treatment for him.

Cost of drug

The price of this drug in pharmacies for twenty tablets varies around 270 rubles, for fifty capsules you will have to pay 550-600 rubles. For "Pangrol 25000" ask 550 rubles for twenty pills. The cost of the medication may vary slightly depending on the distribution network.

The drug "Pangrol 10000": reviews

This drug has only positive reviews. Helps to compensate for the lack of enzymes in pancreatitis. It removes heaviness in the stomach and normalizes the digestive process, stool. It is used in the complex treatment of dysbacteriosis. Allowed to use by children.

Usually pediatricians for babies up to three years are advised to divide the capsule into three parts and take it along with the main meals. Snacks are not counted. Babies are given two mini pills three times a day, rubbing them with milk or cereal. Each capsule contains twenty mini pills. The drug itself has a not very pleasant taste and does not dissolve when mixed in food, so many children complain about the presence of solid particles in the dish.

The drug has shown its effectiveness in the treatment of many diseases associated with disruption of the pancreas and gastrointestinal tract. It turned out to be cheaper than its counterparts. Most patients were satisfied with the result, but they advise not to overdo the treatment, as pancreatic enzymes must produce itself. Many patients note the naturalness and safety of the Pangrol 10000 drug.

The instruction (negative reviews about this medicine are completely absent) describes in detail the algorithm for taking the medication and does not recommend using the drug without a doctor's prescription.

Some patients are unhappy with the cost of medication. It is said that a pack of ten would be ideal for children, and twenty capsules are a bit too much, since for the entire period of treatment only a third of the bottle has to be spent.

In general, the drug "Pangrol 10000" has proven its effectiveness, and its price has fully paid off the positive result that it gives.